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00 per share, an additional 100,000 shares of Common Stock at an exercise price of 1. 50 per share, an additional 396,400 shares of Common Stock at an exercise price of 2. 00 per share and an additional 666,240 shares of Common Stock in connection with the exercise of the Bridge Warrants (currently exercisable at 1. 00 per share). None of such options or warrants are viayra for public resale and such ibdications would be subject to Rule 144 of the Act upon issuance thereof. The exercise of such outstanding options and warrants will dilute the percentage ownership of the Company's stockholders, and any sales in the public market of shares of Common Stock underlying such securities may adversely affect prevailing market prices for the Common Stock. Moreover, the terms upon which the Company will be able to obtain additional equity capital may be adversely affected since the holders of such outstanding securities can be expected to exercise trivastal contre indications viagra respective rights therein at a time when the Company would, in all likelihood, be able to obtain any needed capital on terms more favorable to the Company than those provided in such securities. A substantial number of outstanding warrants contain provisions for cashless exercise. LIMITATION ON DIRECTOR LIABILITY. As permitted by Delaware law, the Company's Certificate of Incorporation limits the liability of directors to the Company or its stockholders for monetary damages for breach sitagliptin normal dose of viagra a director's fiduciary duty except for liability in certain instances.

Detailed information

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The microemulsions of the present invention are useful inter alia for delivering small molecules, proteins (including peptides and polypeptides and chimeras), antibodies, other water soluble molecules as well as oil-soluble molecules useful in treating joint damage. Joint damage may arise through chronic inflammatory disease states such as rheumatoid arthritis and systemic lupus erythematosus (SLE) or in response to acute damage such as that experienced by individuals during sporting activities (e. ankle sprain). Vitamin B 12, for example, is a useful nitric oxide chelator and is useful in reducing joint-related inflammation. The microemulsions of the present invention can be used to deliver nitric oxide and TNF alpha inhibitors to joint tissue to ameliorate conditions such as rheumatoid arthritis and joint damage following acute injury.

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