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The subject microemulsions for transdermal delivery of peptides, polypeptides and proteins or other molecules such as water soluble vitamins, NSAIDs, genetic molecules and chemical compounds are able to be formed with little or no shear force applied to the molecules during the preparation of the microemulsion, which aids in the preservation of the structure and bioactivity of these molecules. The microemulsion also provides both a hydrophilic and hydrophobic environment, which can aid in the solubilization of various molecules and which additionally provides the ability to mix hydrophobic molecules and hydrophilic molecules within the same formulation. Additionally, the microemulsions of the present invention provide an environment which allows for the solubilization of various water- soluble molecules at a wide range of concentrations. Hence, in one aspect, the present invention provides a microemulsion comprising a water phase; an oil phase; an active ingredient; one or more zwitterionic surfactants; and one or more co-surfactants.

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