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The digested fragments can be purified by, for example, high performance liquid chromatographic (HPLC) techniques. Any such fragment, irrespective of its means of generation, is to be understood as being encompassed by the term "derivative" as used herein. The active agent of the present invention may be a chimeric molecule comprising an isolated protein or a fragment thereof, such as an extra-cellular domain of a membrane bound protein, linked to the constant (Fc) or framework region of a human immunoglobulin via one or more protein linkers. Such a chimeric molecule is also referred to herein as protein-Fc.

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The truth is that whatever the hospice diagnoses 8211; heart condition, cancer, COPD, Alzheimer8217;s, etc 8211; at the end of life as the immune system weakens it is precisely the infection that actually provides the mortal coup de grace. When a healthy organism has an infection (think a drop of sewage in an otherwise potable bucket) it makes sense to treat it.]