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Detailed information

The only thing that we do know for sure is that the trial is set to begin on May 10, 2010, just 25 calander days away. Wednesday, April 14, 2010. Time for a field trip to the courthouse.

At the conclusion of the study, the volunteers treated with the topical pharmaceutical composition of the present invention show reduced thickness of sub cutaneous fat deposits of the upper arm, as determined by one or more of the following methods: skinfold caliper measuremen, A-mode ultrasound measurement, B-mode ultrasound measurement; whereas the volunteers treated with placebo have little or no response to treatment. It is anticipated that blood levels of insulin, insulin-like growth factor 1 (IGFl) or GHRP-6 are not affected by treatment with the topical pharmaceutical composition of the present invention. EXAMPLE 19. In vivo determination of physical and biological parameters of the skin of human subjects following topical application of a Pharmaceutical Composition with a Water-in- The individual subjects of the in vivo studies described herein are warm-blooded vertebrate animals, which include humans. A standardized volume of a topical formulation of the present invention selected from Examples 4 or 5 or a placebo formulation is applied to an appropriate area of the body, for example, the forehead or the back of the hand of volunteers in a prescribed fashion for an appropriate period, for example, 6 weeks with biological parameters associated with each skin area being measured at the beginning (baseline measurements before any treatment), end (after the final treatment), and at regular intervals during the study period. Such measurements include : (1) the measurement of skin capacitance using a suitable instrument (for example, a Corneometer CM 825; Courage Khazaka Electronic, KoIn, Germany); (2) the measurement of skin conductance using a suitable instrument (for example, a Skicon-200; ISBS Co.

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